Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29708057 | 0.84 | CHEK1 (0.52) | RETTDP1FLT3CHEK1NEK2 | |
| SCHEMBL346454 | 0.84 | CHEK1 (0.52) | RETTDP1FLT3CHEK1NEK2 | |
| SCHEMBL13486828 | 0.81 | CA2 (0.49) | RETTDP1FLT3CHEK1NEK2 | |
| SCHEMBL11895872 | 0.77 | NFE2L2 (0.53) | RETTDP1CHEK1NEK2LIMK1 | |
| SCHEMBL29403281 | 0.77 | NFE2L2 (0.53) | RETTDP1CHEK1NEK2LIMK1 | |
| SCHEMBL11895869 | 0.77 | NFE2L2 (0.53) | RETTDP1CHEK1NEK2LIMK1 | |
| SCHEMBL154794 | 0.76 | ERN1 (0.61) | TDP1ERN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL12143561 | 0.72 | ERN1 (0.57) | TDP1ERN1KDM4ELMNAHTT | |
| Hydrazine SCHEMBL27868863 | 0.72 | ERN1 (0.57) | TDP1ERN1LMNAALDH1A1MEN1 | |
| SCHEMBL9671258 | 0.72 | ERN1 (0.57) | TDP1ERN1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998008813-A1 | COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |