Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | PPIA | P62937 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NMT1 | P30419 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980925 | 0.90 | ALDH1A1 (0.60) | TSHRPPIAL3MBTL1MAPK10ALDH1A1 | |
| SCHEMBL28877532 | 0.89 | ALDH1A1 (0.56) | TSHRPPIAL3MBTL1MEN1HSP90AA1 | |
| SCHEMBL8980558 | 0.86 | PTGER1 (0.50) | MEN1KMT2AALDH1A1MAOBSMN1; SMN2 | |
| SCHEMBL8980608 | 0.84 | L3MBTL1 (0.55) | L3MBTL1CYP3A4MAOBSMN1; SMN2HTT | |
| SCHEMBL27968967 | 0.84 | TSHR (0.53) | TSHRPPIAL3MBTL1MEN1HSP90AA1 | |
| SCHEMBL15716659 | 0.82 | ALDH1A1 (0.67) | TSHRL3MBTL1KMT2AALDH1A1TDP1 | |
| SCHEMBL28957917 | 0.82 | TSHR (0.50) | TSHRPPIAL3MBTL1MEN1HSP90AA1 | |
| SCHEMBL23796493 | 0.81 | MEN1 (0.59) | TSHRL3MBTL1MEN1HSP90AA1KMT2A | |
| SCHEMBL5313068 | 0.81 | NPC1 (0.50) | L3MBTL1MEN1KMT2AALDH1A1MAOB | |
| SCHEMBL27894245 | 0.80 | PTGER1 (0.47) | L3MBTL1MEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | disclosed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |