Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630823 | 0.86 | KDM4E (0.50) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8705376 | 0.85 | KDM4E (0.40) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8699987 | 0.85 | SLC6A9 (0.46) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8705825 | 0.84 | KDM4E (0.48) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8705791 | 0.84 | KDM4E (0.45) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8446576 | 0.80 | SLC9A1 (0.65) | SLC9A1 | |
| SCHEMBL8700392 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL8703472 | 0.76 | KDM4E (0.41) | KDM4ESLC9A1ALDH1A1GAAHSD17B10 | |
| SCHEMBL7828908 | 0.74 | KDM4E (0.55) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL4937034 | 0.74 | SLC6A9 (0.60) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |