Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.40 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705825 | 0.99 | KDM4E (0.48) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8699987 | 0.86 | SLC6A9 (0.46) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8700566 | 0.86 | KDM4E (0.55) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8705791 | 0.85 | KDM4E (0.45) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8700175 | 0.85 | KDM4E (0.36) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL7158966 | 0.83 | SLC9A1 (0.48) | SMN1; SMN2SLC9A1ALDH1A1LMNATSHR | |
| SCHEMBL8635738 | 0.82 | SLC9A1 (0.47) | SLC9A1ALDH1A1TSHRSLC9A3SLC9A2 | |
| SCHEMBL9259719 | 0.80 | CKS1B (0.41) | — | |
| SCHEMBL2976531 | 0.79 | PIK3C3 (0.39) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL7764853 | 0.79 | SLC9A1 (0.69) | SLC9A1SLC9A3SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |