Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 13/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11195885 | 0.80 | CASP6 (0.75) | CASP6LMNATSHRHCAR3APEX1 | |
| SCHEMBL8809569 | 0.80 | MAPT (0.52) | TSHR | |
| SCHEMBL30978366 | 0.77 | CASP6 (0.57) | CASP6LMNATSHRHCAR3APEX1 | |
| SCHEMBL31548567 | 0.76 | CASP6 (0.64) | CASP6LMNATSHRHCAR3APEX1 | |
| SCHEMBL17197945 | 0.76 | CASP6 (0.68) | CASP6LMNATSHRHCAR3APEX1 | |
| SCHEMBL30978367 | 0.75 | ALDH1A1 (0.60) | CASP6LMNATSHRHCAR3 | |
| SCHEMBL11761567 | 0.75 | ALDH1A1 (0.60) | CASP6LMNATSHRHCAR3 | |
| SCHEMBL31174723 | 0.74 | ALDH1A1 (0.50) | LMNA | |
| SCHEMBL2062065 | 0.74 | ALDH1A1 (0.50) | LMNA | |
| SCHEMBL9557826 | 0.74 | CASP6 (0.66) | CASP6LMNATSHRHCAR3APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834471-A | Amide derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0712397-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004729-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-16 | — | — | WO | disclosed |