Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698539 | 0.96 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL11694913 | 0.79 | HDAC8 (0.75) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL20108460 | 0.78 | ALDH1A1 (0.72) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL8701679 | 0.77 | HDAC1 (0.57) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL8226957 | 0.77 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL7367763 | 0.76 | HDAC1 (0.75) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL4253986 | 0.76 | MAPT (0.56) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL1233439 | 0.76 | HDAC1 (0.66) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL8587363 | 0.76 | HDAC1 (0.75) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL8701697 | 0.75 | ALOX5 (0.43) | HDAC1HDAC2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | claimed |
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |