SCHEMBL8701406

SCHEMBL8701406

CCc1cc(NC(=O)CN2CCN(c3ccccc3OC)CC2)c(OC)nc1C

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.64
ALDH1A1 P00352 7/20 0.64
TSHR P16473 6/20 0.64
MEN1 O00255 6/20 0.64
GAA P10253 1/20 0.60
MAPT P10636 3/20 0.60
DRD4 P21917 1/20 0.60
NPSR1 Q6W5P4 3/20 0.59
CYP1A2 P05177 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
TP53 P04637 1/20 0.58
USP2 O75604 1/20 0.58
KDM4E B2RXH2 2/20 0.58
HTT P42858 1/20 0.57
LMNA P02545 1/20 0.57
SMN1; SMN2 Q16637 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8699351 0.90 ALDH1A1 (0.66) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL8705983 0.87 MAPT (0.57) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL6652670 0.84 PHGDH (0.58) KMT2AALDH1A1MEN1GAAMAPT
SCHEMBL8700078 0.82 MAPT (0.56) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL6673633 0.82 PKM (0.46) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL8704176 0.80 MAPT (0.55) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL6963593 0.80 MAPT (0.54) KMT2AALDH1A1TSHRGAAMAPT
SCHEMBL8704504 0.80 MAPT (0.54) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL8701411 0.80 TACR3 (0.47) KMT2AALDH1A1TSHRMEN1GAA
SCHEMBL9057833 0.80 RBP4 (0.50) KMT2AALDH1A1TSHRMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5780472-A ANTITUMOR AGENTS SAMJIN PHARMACEUTICAZL CO., LTD. (KR) 1998-07-14 US disclosed
WO-1996021648-A1 NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1996-07-18 WO disclosed