Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212819 | 0.84 | TTR (0.53) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| SCHEMBL7207810 | 0.83 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL8701445 | 0.81 | HSD17B10 (0.56) | HSD17B10ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL3924851 | 0.76 | HSD17B10 (0.63) | HSD17B10ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL3923921 | 0.75 | HSD17B10 (0.61) | HSD17B10ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL14519837 | 0.72 | HSD17B10 (0.71) | HSD17B10MEN1KMT2AHTR2AMTNR1A | |
| SCHEMBL11812619 | 0.72 | HSD17B10 (0.61) | HSD17B10ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL3922719 | 0.71 | HSD17B10 (0.69) | HSD17B10ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL7206388 | 0.71 | TSHR (0.41) | ALDH1A1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL7206345 | 0.70 | GABRA1 (0.41) | SMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-A1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER-LAMBERT COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5633287-A | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents | WARNER-LAMBERT COMPANY (US) | 1997-05-27 | — | — | US | disclosed |
| WO-1997005868-A1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER-LAMBERT COMPANY (US) | 1997-02-20 | — | — | WO | disclosed |