Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701443 | 0.83 | HSD17B10 (0.51) | SMN1; SMN2LMNAHTTRAB9ANPC1 | |
| SCHEMBL7212819 | 0.79 | TTR (0.53) | SMN1; SMN2LMNAHTTMAPTKMT2A | |
| SCHEMBL7207814 | 0.78 | NPC1 (0.39) | SMN1; SMN2LMNAHTTRAB9ANPC1 | |
| SCHEMBL7206345 | 0.77 | GABRA1 (0.41) | SMN1; SMN2LMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL7212856 | 0.74 | AKR1B1 (0.41) | LMNAHTTALDH1A1TP53MAPT | |
| SCHEMBL7206388 | 0.72 | TSHR (0.41) | SMN1; SMN2LMNAHTTALDH1A1TP53 | |
| SCHEMBL7109320 | 0.69 | FABP3 (0.35) | — | |
| SCHEMBL7211115 | 0.68 | CYP1A1 (0.45) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL7207616 | 0.68 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAHTTRAB9ANPC1 | |
| SCHEMBL1599400 | 0.66 | HSD17B10 (0.56) | SMN1; SMN2LMNAALDH1A1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |