Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697968 | 0.82 | HDAC3 (0.57) | HDAC3HDAC1HDAC6PTPN5LMNA | |
| SCHEMBL8697858 | 0.80 | HDAC3 (0.64) | HDAC3HDAC1HDAC6PTPN5LMNA | |
| SCHEMBL9055298 | 0.76 | YES1 (0.65) | HDAC3HDAC1HDAC6PTPN5LMNA | |
| SCHEMBL8701787 | 0.73 | HDAC10 (0.44) | HDAC1HDAC6MAPTKMT2AMEN1 | |
| SCHEMBL8804198 | 0.71 | NOTUM (0.62) | HDAC3HDAC1HDAC6PTPN5LMNA | |
| SCHEMBL8701532 | 0.70 | ALDH1A1 (0.46) | MAPTALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL24247573 | 0.69 | TP53 (0.67) | HDAC3HDAC1HDAC6LMNATP53 | |
| SCHEMBL7440886 | 0.69 | ALDH1A1 (0.54) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8701794 | 0.69 | KMT2A (0.52) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL1225107 | 0.68 | TP53 (0.65) | HDAC3HDAC1HDAC6LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | claimed |
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |