Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.33 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.33 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704076 | 0.91 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8705723 | 0.85 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8700661 | 0.85 | SLC9A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8705014 | 0.83 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8703959 | 0.83 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8704528 | 0.83 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8702119 | 0.82 | SLC9A1 (0.46) | SLC9A1SLC9A3SLC9A2KMT2A | |
| SCHEMBL8705327 | 0.81 | HTT (0.41) | MEN1KMT2A | |
| SCHEMBL8700666 | 0.80 | GAA (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8703753 | 0.80 | NR3C1 (0.33) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |