Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700661 | 0.88 | SLC9A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8705723 | 0.86 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8704076 | 0.85 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8447882 | 0.84 | SLC9A1 (0.53) | — | |
| SCHEMBL8701748 | 0.83 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8700666 | 0.83 | GAA (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8704528 | 0.83 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8703959 | 0.83 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8701738 | 0.80 | SLC9A1 (0.49) | NR1I2FGFR1SRC | |
| SCHEMBL8704442 | 0.80 | AAK1 (0.45) | NR1I2TSHRMAPK1FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |