Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GLP1R | P43220 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8703753 | 0.91 | NR3C1 (0.33) | MAPTKDM4EKMT2ANPSR1GLP1R | |
| SCHEMBL8705953 | 0.85 | NR1I2 (0.40) | MAPTKDM4EKMT2ANPSR1MAPK1 | |
| SCHEMBL8705223 | 0.85 | NR3C1 (0.37) | MAPTKDM4EKMT2ANPSR1NR1H2 | |
| SCHEMBL8702046 | 0.85 | KDM4E (0.39) | MAPTKDM4ENPSR1 | |
| SCHEMBL8704520 | 0.83 | SLC9A1 (0.31) | — | |
| SCHEMBL8699344 | 0.83 | GAA (0.42) | MAPTKDM4EKMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL8704804 | 0.83 | MAPT (0.33) | MAPTKDM4EKMT2ANPSR1NR3C1 | |
| SCHEMBL8705360 | 0.82 | MAPT (0.33) | MAPTKDM4EKMT2ANPSR1NR1H2 | |
| SCHEMBL8705762 | 0.82 | SDHB (0.37) | MAPTPTGS2NR1H2 | |
| SCHEMBL8446137 | 0.81 | SLC9A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |