Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599971 | 0.82 | EPHX2 (0.49) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL28510375 | 0.81 | EGFR (0.48) | ALDH1A1HDAC1HDAC8MAPK1PRMT1 | |
| SCHEMBL10687684 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28143552 | 0.77 | HDAC1 (0.53) | ALDH1A1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL398043 | 0.77 | TBXA2R (0.42) | ALDH1A1RAB9A | |
| SCHEMBL7053278 | 0.76 | BCAT1 (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL7652696 | 0.74 | ALDH1A1 (0.42) | ALDH1A1ADRA1ASMN1; SMN2KMT2ARAB9A | |
| SCHEMBL162806 | 0.74 | HDAC1 (0.62) | ALDH1A1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL2222140 | 0.73 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL19452424 | 0.73 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214281-B | Synthesis of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives and application of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives in anticancer drugs | 济宁市第一人民医院 | 2022-05-17 | — | — | CN | claimed |
| CN-113214281-A | Synthesis of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives and application of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives in anticancer drugs | 济宁市第一人民医院 | 2021-08-06 | — | — | CN | claimed |
| US-5792451-A | AMINO ACID DERIVATIVES AS CARRIERS FOR SENSITIVE AGENTS SUCH AS BIOACTIVE PEPTIDES | EMISPHERE TECHNOLOGIES, INC. (US) | 1998-08-11 | — | — | US | claimed |
| CN-113214281-B | Synthesis of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives and application of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives in anticancer drugs | 济宁市第一人民医院 | 2022-05-17 | — | — | CN | disclosed |
| CN-113214281-B | Synthesis of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives and application of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives in anticancer drugs | 济宁市第一人民医院 | 2022-05-17 | — | — | CN | disclosed |
| CN-113214281-A | Synthesis of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives and application of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives in anticancer drugs | 济宁市第一人民医院 | 2021-08-06 | — | — | CN | disclosed |
| CN-113214281-A | Synthesis of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives and application of benzene sulfonamide phenylbutyrate podophyllotoxin ester derivatives in anticancer drugs | 济宁市第一人民医院 | 2021-08-06 | — | — | CN | disclosed |