SCHEMBL8707495

SCHEMBL8707495

CC(C)(C)c1ccccc1-c1cccc(O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN5 P54829 1/20 0.48
HSD17B1 P14061 12/20 0.47
HSD17B2 P37059 11/20 0.47
CYP2C9 P11712 2/20 0.47
CYP3A4 P08684 1/20 0.47
CA2 P00918 1/20 0.47
ALDH1A1 P00352 2/20 0.45
TRPA1 O75762 1/20 0.45
TSHR P16473 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
NR1I2 O75469 1/20 0.42
LMNA P02545 1/20 0.42
MIF P14174 1/20 0.42
TYR P14679 1/20 0.42
ALOX15 P16050 1/20 0.42
HTT P42858 1/20 0.42
NFE2L2 Q16236 1/20 0.42
HSD17B10 Q99714 1/20 0.42
BAZ2B Q9UIF8 1/20 0.42
BAZ2A Q9UIF9 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30194426 0.89 HSD17B1 (0.47) PTPN5HSD17B1HSD17B2CYP2C9CYP3A4
SCHEMBL1027860 0.81 SCN9A (0.53) HSD17B1HSD17B2CYP2C9CYP3A4ALDH1A1
SCHEMBL8708320 0.81 HSD17B1 (0.42) PTPN5HSD17B1HSD17B2CYP2C9CYP3A4
SCHEMBL4779452 0.80 HSD17B1 (0.64) HSD17B1HSD17B2CYP2C9CYP3A4CA2
SCHEMBL6839847 0.79 ALDH1A1 (0.50) CYP2C9CYP3A4CA2ALDH1A1TRPA1
SCHEMBL29521739 0.78 MAOA (0.50) PTPN5CYP3A4CA2ALDH1A1TRPA1
SCHEMBL28301348 0.78 MAOA (0.50) PTPN5CYP3A4CA2ALDH1A1TRPA1
SCHEMBL9261126 0.78 TRPA1 (0.45) PTPN5HSD17B1HSD17B2CA2TRPA1
SCHEMBL9258898 0.78 TRPA1 (0.45) PTPN5TRPA1TSHR
SCHEMBL291792 0.78 ALDH1A1 (0.46) PTPN5CA2ALDH1A1TRPA1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0852486-A2 ANTIPLAQUE ORAL COMPOSITION Colgate-Palmolive Company (US) 1998-07-15 EP claimed
US-5723500-A WATER INSOLUBLE, NONCATIONIC, ANTIBACTERIAL, STERICALLY HINDERED PHENOL; MOUTHWASHES, DENTIFRICES COLGATE-PALMOLIVE COMPANY (US) 1998-03-03 US claimed
WO-1997010800-A2 ANTIPLAQUE ORAL COMPOSITION COLGATE-PALMOLIVE COMPANY (US) 1997-03-27 WO claimed
EP-0852486-A2 ANTIPLAQUE ORAL COMPOSITION Colgate-Palmolive Company (US) 1998-07-15 EP disclosed
US-5723500-A WATER INSOLUBLE, NONCATIONIC, ANTIBACTERIAL, STERICALLY HINDERED PHENOL; MOUTHWASHES, DENTIFRICES COLGATE-PALMOLIVE COMPANY (US) 1998-03-03 US disclosed
WO-1997010800-A2 ANTIPLAQUE ORAL COMPOSITION COLGATE-PALMOLIVE COMPANY (US) 1997-03-27 WO disclosed