Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DVL1 | O14640 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708703 | 1.00 | MAPT (0.53) | MAPTDNM1KMT2AALDH1A1MEN1 | |
| SCHEMBL8708414 | 0.96 | MAPT (0.52) | MAPTDNM1KMT2AALDH1A1MEN1 | |
| SCHEMBL8310527 | 0.91 | MAPT (0.59) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8307204 | 0.83 | DNM1 (0.62) | MAPTDNM1KMT2AALDH1A1MEN1 | |
| SCHEMBL8532182 | 0.80 | MEN1 (0.66) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8532185 | 0.80 | MEN1 (0.66) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8307610 | 0.77 | MAPT (0.80) | MAPTKMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL8712470 | 0.77 | ADAMTS5 (0.71) | ADAMTS5AKR1B1 | |
| SCHEMBL8308209 | 0.76 | MAPT (0.61) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL541143 | 0.75 | MAPT (0.89) | MAPTKMT2AALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0599485-B1 | Method of inhibiting corrosion in aqueous systems | BETZ EUROP INC (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0599485-A1 | Method of inhibiting corrosion in aqueous systems | BETZ EUROPE, INC. (US) | 1994-06-01 | — | — | EP | disclosed |