Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219681 | 0.93 | ADAMTS5 (0.84) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL5219686 | 0.93 | ADAMTS5 (0.84) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL14901147 | 0.87 | FABP4 (0.74) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL7142543 | 0.86 | ADAMTS5 (0.80) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL7142541 | 0.86 | ADAMTS5 (0.80) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL12008625 | 0.86 | CTNNB1 (0.69) | ADAMTS5 | |
| SCHEMBL12008627 | 0.86 | APAF1 (0.66) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL10492195 | 0.86 | MEN1 (0.65) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL10492192 | 0.86 | MEN1 (0.65) | ADAMTS5AKR1B1PTPN1 | |
| SCHEMBL12008416 | 0.86 | CTNNB1 (0.75) | ADAMTS5AKR1B1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | claimed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |