Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | PI4KA | P42356 | 3/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | POLA1 | P09884 | 1/20 | 0.49 |
| ▸ | POLG | P54098 | 1/20 | 0.49 |
| ▸ | FAP | Q12884 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | AHCY | P23526 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302562 | 0.84 | FGFR1 (0.64) | ENPP1SLC22A6FGFR1ADORA2AADORA1 | |
| SCHEMBL9127175 | 0.82 | PI4KA (0.46) | ENPP1SLC22A6FGFR1ADORA2AADORA1 | |
| SCHEMBL8709241 | 0.81 | HSP90AB1 (0.43) | — | |
| SCHEMBL8897180 | 0.80 | SLC22A6 (0.72) | ENPP1SLC22A6FGFR1ADORA2AADORA1 | |
| SCHEMBL8927904 | 0.79 | SLC22A6 (0.70) | ENPP1SLC22A6FGFR1ADORA2AADORA1 | |
| SCHEMBL8895414 | 0.79 | SLC22A6 (0.70) | ENPP1SLC22A6FGFR1ADORA2AADORA1 | |
| SCHEMBL13648201 | 0.78 | ENPP1 (0.65) | ENPP1SLC22A6FGFR1ADORA2AADORA1 | |
| SCHEMBL2582709 | 0.78 | CYP3A4 (0.67) | ADORA2AADORA1CYP3A4FAPCYP2D6 | |
| SCHEMBL2578605 | 0.78 | CYP3A4 (0.67) | ADORA2AADORA1CYP3A4FAPCYP2D6 | |
| SCHEMBL8709070 | 0.77 | FAP (0.56) | ENPP1SLC22A6FGFR1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726174-A | VIRICIDES, ANTITUMOR AGENTS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1998-03-10 | — | — | US | disclosed |
| US-5696265-A | ANTIRETROVIRAL; ANTITUNOR AGENT | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-12-09 | — | — | US | disclosed |
| US-5693798-A | ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-12-02 | — | — | US | disclosed |
| US-5688778-A | VIRICIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-11-18 | — | — | US | disclosed |
| US-5686611-A | Nucleoside analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-11-11 | — | — | US | disclosed |
| EP-0398231-B1 | Nucleoside analogs | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1997-07-16 | — | — | EP | disclosed |
| EP-0398231-A2 | Nucleoside analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1990-11-22 | — | — | EP | disclosed |