SCHEMBL8709241

SCHEMBL8709241

CCC(CC)(OCOCn1cnc2c(Cl)nc(N)nc21)P(=O)(O)O

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 15/20 0.43
HSP90AA1 P07900 14/20 0.43
HDAC1 Q13547 3/20 0.43
HDAC6 Q9UBN7 3/20 0.43
HDAC4 P56524 1/20 0.43
HDAC2 Q92769 1/20 0.42
HSP90B1 P14625 1/20 0.41
TRAP1 Q12931 1/20 0.41
PNP P00491 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8713510 0.84 MEN1 (0.41) HDAC1HDAC6HDAC4HDAC2PNP
SCHEMBL8709090 0.81 ENPP1 (0.56)
SCHEMBL8709228 0.78 HSP90AB1 (0.47) HSP90AB1HSP90AA1HDAC1HDAC6HDAC4
SCHEMBL8400867 0.77 HSP90AB1 (0.45) HSP90AB1HSP90AA1HDAC1HDAC6HDAC4
SCHEMBL28482012 0.76 HSP90AB1 (0.41) HSP90AB1HSP90AA1HDAC1HDAC6HDAC4
SCHEMBL7590077 0.73 CYP2C19 (0.53) PNP
SCHEMBL14916463 0.72 HSP90AB1 (0.50) HSP90AB1HSP90AA1HSP90B1TRAP1PNP
SCHEMBL6837988 0.72 HDAC1 (0.44) HSP90AB1HSP90AA1HDAC1HDAC6HDAC4
SCHEMBL8895990 0.72 HSP90AB1 (0.39) HSP90AB1HSP90AA1HDAC1HDAC6HDAC4
SCHEMBL9366819 0.72 MEN1 (0.56) HSP90AB1HSP90AA1HDAC1HDAC6HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5837871-A PHOSPHONATE DERIVATIVES; ANTITUMOR AGENTS, VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-11-17 US disclosed
US-5726174-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-03-10 US disclosed
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US disclosed
US-5693798-A ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-02 US disclosed
US-5688778-A VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-18 US disclosed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US disclosed
EP-0398231-B1 Nucleoside analogs ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-07-16 EP disclosed