Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709273 | 0.92 | XDH (0.40) | SLC22A12XDHS1PR1S1PR3RAB9A | |
| SCHEMBL8709829 | 0.83 | XDH (0.40) | XDHS1PR1S1PR3RAB9ANPC1 | |
| SCHEMBL8710246 | 0.83 | XDH (0.40) | XDHRAB9ANPC1LMNAGRM4 | |
| SCHEMBL8712836 | 0.79 | MAPK8 (0.37) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL8710268 | 0.79 | XDH (0.43) | XDHRAB9ANPC1MEN1KMT2A | |
| SCHEMBL8712687 | 0.78 | POLB (0.38) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL8710521 | 0.78 | CNR2 (0.36) | RAB9AMEN1KMT2ALMNAPOLB | |
| SCHEMBL8713114 | 0.78 | CLCN2 (0.39) | POLB | |
| SCHEMBL8715277 | 0.77 | CLCN2 (0.38) | RAB9AMEN1KMT2ALMNAPOLB | |
| SCHEMBL8713191 | 0.77 | MAPK8 (0.39) | RAB9ANPC1HPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |