Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048299 | 0.93 | PKM (0.39) | MEN1KMT2AALDH1A1BLMNPC1 | |
| SCHEMBL8033976 | 0.92 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8711532 | 0.91 | NPC1 (0.38) | MEN1KMT2AALDH1A1BLMNPC1 | |
| SCHEMBL8047480 | 0.87 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8043014 | 0.84 | RECQL (0.49) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8042895 | 0.82 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8711373 | 0.80 | CSNK1D (0.47) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8042782 | 0.78 | PKM (0.39) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8052304 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8044961 | 0.77 | MEN1 (0.44) | MEN1KMT2AALDH1A1HPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |