Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.38 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.38 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.38 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709132 | 0.92 | EPHX2 (0.41) | MAPTALDH1A1ITGB3ITGAVNLRP3 | |
| SCHEMBL8704794 | 0.92 | ALDH1A1 (0.43) | MAPTALDH1A1ITGB3ITGAVNLRP3 | |
| SCHEMBL8710102 | 0.92 | EPHX2 (0.42) | MAPTALDH1A1ITGB3ITGAVMEN1 | |
| SCHEMBL8705303 | 0.91 | MAPT (0.40) | MAPTALDH1A1ITGB3ITGAVMEN1 | |
| SCHEMBL8709538 | 0.91 | NR1H4 (0.42) | MAPTALDH1A1ITGB3ITGAVNLRP3 | |
| SCHEMBL8709447 | 0.91 | ITGB3 (0.48) | MAPTALDH1A1ITGB3ITGAVMEN1 | |
| SCHEMBL8709894 | 0.91 | FLT1 (0.44) | MAPTALDH1A1ITGB3ITGAVMEN1 | |
| SCHEMBL8706028 | 0.91 | MAPT (0.41) | MAPTALDH1A1ITGB3ITGAVNLRP3 | |
| SCHEMBL8709625 | 0.90 | NLRP3 (0.43) | MAPTALDH1A1ITGB3ITGAVNLRP3 | |
| SCHEMBL8709556 | 0.89 | MEN1 (0.43) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998041515-A1 | ENDOTHOLIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-24 | — | — | WO | disclosed |