Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16696407 | 0.85 | RAB9A (0.47) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL7558526 | 0.84 | NLRP3 (0.54) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2C19 | |
| SCHEMBL29666364 | 0.76 | RAB9A (0.70) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL7554735 | 0.75 | NLRP3 (0.45) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2C19 | |
| SCHEMBL16374744 | 0.75 | RAB9A (0.68) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL30729910 | 0.74 | SMN1; SMN2 (0.54) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL30445349 | 0.74 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL4593845 | 0.74 | L3MBTL1 (0.55) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL21059157 | 0.74 | RAB9A (0.73) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 | |
| SCHEMBL4852614 | 0.74 | NLRP3 (0.63) | RAB9ASMN1; SMN2NPC1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |