SCHEMBL8710677

SCHEMBL8710677

O=C1N=Cc2cnccc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
CDC25B P30305 1/20 0.41
PDE3B Q13370 4/20 0.34
PDE3A Q14432 4/20 0.34
MAPT P10636 3/20 0.33
TP53 P04637 2/20 0.33
CYP3A4 P08684 2/20 0.33
CASP1 P29466 2/20 0.33
BLM P54132 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP7 P55210 1/20 0.33
FEN1 P39748 1/20 0.33
KDM4E B2RXH2 1/20 0.33
KDM4C Q9H3R0 2/20 0.32
KDM4A O75164 1/20 0.32
KDM4B O94953 1/20 0.32
KDM5C P41229 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30227719 1.00 MAOA (0.42) MAOAMAOBCDC25BPDE3BPDE3A
SCHEMBL2657717 0.83 MAOA (0.42) MAOAMAOBCDC25BPDE3BPDE3A
SCHEMBL23645371 0.81 MAOA (0.41) MAOAMAOBCDC25BPDE3BPDE3A
Hydrochloric Acid SCHEMBL7086045 0.81 MAOA (0.41) MAOAMAOBCDC25BPDE3BPDE3A
Octane SCHEMBL5764314 0.70 KDM4E (0.38) CYP3A4KDM4EKDM4CGSK3B
SCHEMBL113314 0.70 GSK3B (0.40) MAOAMAOBCDC25BMAPTTP53
SCHEMBL29394879 0.70 GSK3B (0.40) MAOAMAOBCDC25BMAPTTP53
SCHEMBL3709717 0.69 MAOA (0.38) MAOAMAOBCDC25BPDE3BPDE3A
Hydrochloric Acid SCHEMBL20475155 0.68 GSK3B (0.39) MAOAMAOBCDC25BMAPTTP53
SCHEMBL30130240 0.65 SIGMAR1 (0.36) MAOAMAOBPDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023057882-A1 COMBINATIONS OF AZALACTAM COMPOUNDS WITH A PD-1 AXIS BINDING ANTAGONIST FOR THE TREATMENT OF CANCER PFIZER INC. (US) 2023-04-13 WO claimed
EP-4143186-A1 AZALACTAM COMPOUNDS AS HPK1 INHIBITORS Pfizer Inc. (US) 2023-03-08 EP claimed
WO-2021220185-A1 AZALACTAM COMPOUNDS AS HPK1 INHIBITORS PFIZER INC. (US) 2021-11-04 WO claimed
US-20260085045-A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) 2026-03-26 US disclosed
WO-2025264837-A1 NAPHTHYRIDINE GPR52 MODULATORS AND METHODS OF USE THEREOF LIEBER INSTITUTE, INC. (US) 2025-12-26 WO disclosed
US-12441725-B2 ISO-citrate dehydrogenase (IDH) inhibitor ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) 2025-10-14 US disclosed
US-12240836-B2 Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof DONG-A ST CO., LTD. (KR) 2025-03-04 US disclosed
US-20240197703-A1 Azalactam Compounds as HPK1 Inhibitors PFIZER INC. (US) 2024-06-20 US disclosed
US-20240116917-A1 ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) 2024-04-11 US disclosed
US-20240025884-A1 COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF DONG-A ST CO., LTD. (KR) 2024-01-25 US disclosed
EP-3880676-B1 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER PFIZER (US) 2023-08-02 EP disclosed
US-20220401424-A1 Azalactam Compounds as HPK1 Inhibitors PFIZER INC. (US) 2022-12-22 US disclosed
WO-2021220185-A1 AZALACTAM COMPOUNDS AS HPK1 INHIBITORS PFIZER INC. (US) 2021-11-04 WO disclosed
US-11142525-B2 Azalactam compounds as HPK1 inhibitors PFIZER INC. (US) 2021-10-12 US disclosed
EP-3880676-A1 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER Pfizer Inc. (US) 2021-09-22 EP disclosed
US-20200172539-A1 Azalactam Compounds as HPK1 Inhibitors PFIZER INC. (US) 2020-06-04 US disclosed
WO-2020100027-A1 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER PFIZER INC. (US) 2020-05-22 WO disclosed
EP-2885300-A1 TRIS(HETERO)ARYLPYRAZOLES AND USE THEREOF AiCuris GmbH & Co. KG (DE) 2015-06-24 EP disclosed
WO-2014027112-A1 TRIS(HETERO)ARYLPYRAZOLES AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2014-02-20 WO disclosed
WO-1998042666-A1 NOVEL 3,4-DIALKOXYPHENYL DERIVATIVES AND THE USE THEREOF DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 1998-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116917-A1 ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR IDH2, IDH3A, IDH1 MAOA 4614/4885MAOB 4568/4885CDC25B 890/4885
US-20220401424-A1 Azalactam Compounds as HPK1 Inhibitors CDKN1A, HIPK1, CMPK1 MAOA 3172/4885MAOB 3159/4885CDC25B 590/4885
US-20200172539-A1 Azalactam Compounds as HPK1 Inhibitors CDKN1A, HIPK1, CMPK1 MAOA 2353/4885MAOB 3949/4885CDC25B 919/4885
US-12240836-B2 Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof EIF2AK4, GCN1, GCGR MAOA 2614/4885MAOB 2265/4885CDC25B 3172/4885
US-11142525-B2 Azalactam compounds as HPK1 inhibitors CDKN1A, HIPK1, CMPK1 MAOA 2353/4885MAOB 3949/4885CDC25B 919/4885
US-20260085045-A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF NPR1, CBR1, NAT1 MAOA 341/4885MAOB 460/4885CDC25B 3112/4885
US-20240025884-A1 COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF EIF2AK4, GCN1, GCGR MAOA 2614/4885MAOB 2265/4885CDC25B 3172/4885
US-20240197703-A1 Azalactam Compounds as HPK1 Inhibitors CDKN1A, HIPK1, CMPK1 MAOA 3172/4885MAOB 3159/4885CDC25B 590/4885
US-12441725-B2 ISO-citrate dehydrogenase (IDH) inhibitor IDH2, IDH3A, IDH1 MAOA 4614/4885MAOB 4568/4885CDC25B 890/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.