Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712282 | 0.89 | ESR1 (0.60) | ESR1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL1629150 | 0.83 | KEAP1 (0.77) | KEAP1NFE2L2 | |
| SCHEMBL10300192 | 0.79 | ESR1 (0.49) | ESR1ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL15833703 | 0.79 | SMN1; SMN2 (0.65) | ALDH1A1LMNASMN1; SMN2MAPTKEAP1 | |
| SCHEMBL8714947 | 0.78 | ESR1 (0.63) | ESR1ALDH1A1LMNAHPGDHTT | |
| SCHEMBL6096889 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1HPGDHTTSMN1; SMN2MEN1 | |
| SCHEMBL6096893 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1HPGDHTTSMN1; SMN2MEN1 | |
| SCHEMBL6096525 | 0.77 | MET (0.69) | SMN1; SMN2KEAP1NFE2L2NPSR1MMP1 | |
| SCHEMBL6096531 | 0.77 | MET (0.69) | SMN1; SMN2KEAP1NFE2L2NPSR1MMP1 | |
| SCHEMBL4936946 | 0.76 | SMN1; SMN2 (0.77) | LMNAHTTSMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |