Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661948 | 0.88 | MEN1 (0.55) | KMT2AMEN1POLBALDH1A1P2RX7 | |
| SCHEMBL8694224 | 0.79 | MEN1 (0.64) | KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7163528 | 0.79 | AKR1C3 (0.40) | KMT2AMEN1ALDH1A1TP53HPGD | |
| SCHEMBL8661222 | 0.79 | MEN1 (0.48) | KMT2AMEN1POLBALDH1A1P2RX7 | |
| SCHEMBL8919380 | 0.78 | KMT2A (0.48) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL8527399 | 0.74 | KMT2A (0.43) | KMT2AMEN1POLBALDH1A1TP53 | |
| SCHEMBL8713633 | 0.73 | PKM (0.55) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL8710997 | 0.73 | MEN1 (0.54) | KMT2AMEN1POLBP2RX7 | |
| SCHEMBL10704901 | 0.71 | MGLL (0.55) | ALDH1A1TP53HPGDAKR1C3MAPK14 | |
| SCHEMBL11608600 | 0.71 | MEN1 (0.50) | KMT2AMEN1ALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821372-A | USEFUL FOR INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEIN LEVELS(HDL) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-13 | — | — | US | claimed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | claimed |
| US-5821372-A | USEFUL FOR INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEIN LEVELS(HDL) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-13 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |