Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661948 | 0.77 | MEN1 (0.55) | ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL11268915 | 0.75 | ALDH1A1 (0.54) | PKMALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL8478370 | 0.73 | POLB (0.51) | ALDH1A1HPGDPOLBKMT2AMEN1 | |
| SCHEMBL8710977 | 0.73 | KMT2A (0.44) | ALDH1A1HPGDPOLBKMT2AMEN1 | |
| SCHEMBL8664639 | 0.73 | MEN1 (0.52) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL8710997 | 0.73 | MEN1 (0.54) | SMN1; SMN2POLBKMT2AMEN1MAPT | |
| SCHEMBL8661222 | 0.73 | MEN1 (0.48) | ALDH1A1POLBKMT2AMEN1HTT | |
| SCHEMBL10785120 | 0.73 | POLB (0.60) | ALDH1A1HPGDSMN1; SMN2POLBKMT2A | |
| SCHEMBL9013865 | 0.72 | POLB (0.46) | POLBKMT2AMEN1CYP3A4GAA | |
| SCHEMBL9013730 | 0.72 | POLB (0.60) | ALDH1A1HPGDSMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821372-A | USEFUL FOR INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEIN LEVELS(HDL) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-13 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |