Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705645 | 0.92 | MEN1 (0.41) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8706028 | 0.92 | MAPT (0.41) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8706016 | 0.91 | NPC1 (0.44) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8709884 | 0.91 | MAPT (0.41) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8709556 | 0.91 | MEN1 (0.43) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8709452 | 0.89 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8705691 | 0.89 | MAPT (0.50) | MAPTSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL8709132 | 0.88 | EPHX2 (0.41) | MAPTSMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL8712501 | 0.87 | MAPT (0.39) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8709538 | 0.87 | NR1H4 (0.42) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998041515-A1 | ENDOTHOLIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-24 | — | — | WO | disclosed |