Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.37 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709414 | 0.92 | POLB (0.41) | SMN1; SMN2CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL8705691 | 0.88 | MAPT (0.50) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8709132 | 0.88 | EPHX2 (0.41) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8711019 | 0.87 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8709452 | 0.87 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8709538 | 0.86 | NR1H4 (0.42) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8706028 | 0.84 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8709625 | 0.84 | NLRP3 (0.43) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8709884 | 0.84 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8705303 | 0.83 | MAPT (0.40) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998041515-A1 | ENDOTHOLIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-24 | — | — | WO | disclosed |