Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15283335 | 0.77 | HTR2A (0.37) | RETHTR2AHTR6SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL7951349 | 0.74 | HTR2A (0.36) | RETHTR2AHTR6SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL812413 | 0.70 | HTR2A (0.33) | RETHTR2AHTR6SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL29574347 | 0.70 | HTR2A (0.33) | RETHTR2AHTR6SIGMAR1LMNA | |
| SCHEMBL4516491 | 0.68 | RET (0.42) | RETHTR2AHTR6SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL7937302 | 0.67 | HTR2A (0.37) | RETHTR2AHTR6SIGMAR1LMNA | |
| Fluoride Ion SCHEMBL1130437 | 0.67 | HTR2A (0.33) | RETHTR2AHTR6SIGMAR1LMNA | |
| Bromide SCHEMBL31279860 | 0.67 | HTR2A (0.41) | RETHTR2AHTR6SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL8560765 | 0.67 | HTR6 (0.31) | HTR2AHTR6CYP2D6 | |
| Hydrochloric Acid SCHEMBL8716103 | 0.67 | RET (0.35) | RETHTR2AHTR6SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669346-B1 | Solid catalyst components for olefin polymerization and use thereof | NIPPON OIL CO LTD (JP) | 1998-06-03 | — | — | EP | disclosed |
| US-5604170-A | EFFECTIVE CATALYST SUPPORT SATISFYING CERTAIN REQUISITES: PARTICLE DIAMETER, SPECIFIC SURFACE AREA, PORE VOLUME, SPECIFIC GRAVITY; SUBJECTED TO ULTRASONIC DISINTEGRATION | NIPPON OIL COMPANY, LIMITED (JP) | 1997-02-18 | — | — | US | disclosed |
| EP-0669346-A1 | Solid catalyst components for olefin polymerization and use thereof | NIPPON OIL CO. LTD. (JP) | 1995-08-30 | — | — | EP | disclosed |
| EP-0411937-A2 | Catalyst for polymerization of olefins | Tonen Corporation (JP) | 1991-02-06 | — | — | EP | disclosed |