Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712961 | 1.00 | RAB9A (0.43) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8772954 | 0.87 | KCNMA1 (0.38) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8709190 | 0.85 | KCNMA1 (0.38) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8709192 | 0.85 | KCNMA1 (0.38) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8709935 | 0.83 | RAB9A (0.40) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8709931 | 0.83 | RAB9A (0.40) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8714961 | 0.81 | TLR7 (0.36) | KDM4ECYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8714957 | 0.81 | TLR7 (0.36) | KDM4ECYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8772947 | 0.78 | KCNMA1 (0.48) | RAB9ASMN1; SMN2ALDH1A1HPGDKCNMA1 | |
| SCHEMBL8713261 | 0.77 | KDM4E (0.42) | RAB9AALDH1A1HPGDNPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |