Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709190 | 0.92 | KCNMA1 (0.38) | KCNMA1KDRCCR9CA1CA2 | |
| SCHEMBL8709192 | 0.92 | KCNMA1 (0.38) | KCNMA1KDRCCR9CA1CA2 | |
| SCHEMBL8710237 | 0.89 | GRM4 (0.34) | TLR7GRM4LMNAPOLBALDH1A1 | |
| SCHEMBL8710242 | 0.89 | GRM4 (0.34) | TLR7GRM4LMNAPOLBALDH1A1 | |
| SCHEMBL8712965 | 0.87 | RAB9A (0.43) | KCNMA1KDRCA1CA2P2RX1 | |
| SCHEMBL8712961 | 0.87 | RAB9A (0.43) | KCNMA1KDRCA1CA2P2RX1 | |
| SCHEMBL8710049 | 0.86 | MAPT (0.35) | KDRGRM5GRM4NPC1LMNA | |
| SCHEMBL8711983 | 0.86 | GSTA1 (0.41) | TLR7GRM4NPC1LMNASMN1; SMN2 | |
| SCHEMBL8710053 | 0.86 | MAPT (0.35) | KDRGRM5GRM4NPC1LMNA | |
| SCHEMBL8711981 | 0.86 | GSTA1 (0.41) | TLR7GRM4NPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |