Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713426 | 0.80 | LMNA (0.46) | LMNAHPGDNPC1RAB9AHTT | |
| SCHEMBL8710643 | 0.78 | LMNA (0.63) | LMNAHPGDNPC1RAB9AHTT | |
| SCHEMBL9226595 | 0.75 | HTR2A (0.42) | LMNAKMT2AKDM4E | |
| SCHEMBL8713891 | 0.74 | LMNA (0.64) | LMNAHPGDNPC1RAB9AHTT | |
| SCHEMBL2499084 | 0.70 | KMT2A (0.53) | LMNAHPGDNPC1RAB9AHTT | |
| SCHEMBL9230549 | 0.70 | HSD11B1 (0.57) | LMNAHTTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12193490 | 0.69 | KMT2A (0.67) | HPGDRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2549019 | 0.69 | KDM4C (0.43) | LMNANPC1RAB9AHTTMEN1 | |
| SCHEMBL1763723 | 0.69 | KMT2A (0.57) | LMNAHPGDRAB9AMEN1KMT2A | |
| Oxalic Acid SCHEMBL9217850 | 0.68 | HSD11B1 (0.55) | LMNAHTTKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |