Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713891 | 0.85 | LMNA (0.64) | LMNAHTTGAAHPGDCES2 | |
| SCHEMBL6784816 | 0.80 | PTGES (0.60) | LMNAHTTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8713421 | 0.78 | LMNA (0.53) | LMNAHTTHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL29138562 | 0.78 | ADORA2A (0.45) | LMNAHTTSMN1; SMN2ALDH1A1TSPO | |
| SCHEMBL9230549 | 0.76 | HSD11B1 (0.57) | LMNAHTTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15835211 | 0.75 | KDM4E (0.50) | LMNAHTTGAAHPGDMAPK1 | |
| SCHEMBL1645813 | 0.74 | LIMK1 (0.44) | LMNAHTTL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1926940 | 0.74 | TRPM8 (0.53) | LMNAHPGDCES2CES1MAPK1 | |
| SCHEMBL6778747 | 0.73 | NPC1 (0.55) | LMNAMAPK1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21425705 | 0.72 | MEN1 (0.60) | HPGDCES2CES1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |