Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713421 | 0.80 | LMNA (0.53) | LMNAHPGDALDH1A1MAPK1MEN1 | |
| SCHEMBL8713891 | 0.67 | LMNA (0.64) | LMNAHPGDALDH1A1MAPK1TSHR | |
| SCHEMBL25621200 | 0.66 | HPGD (0.47) | LMNAHPGDALDH1A1GAANPC1 | |
| SCHEMBL8710643 | 0.66 | LMNA (0.63) | LMNAHPGDALDH1A1MAPK1MEN1 | |
| SCHEMBL5987851 | 0.66 | DHFR (0.48) | LMNAHPGDALDH1A1MAPTNPC1 | |
| SCHEMBL3058714 | 0.66 | ALDH1A1 (0.46) | LMNAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL12989210 | 0.65 | CES2 (0.61) | MAPK1MEN1KMT2ACES2CES1 | |
| SCHEMBL5727243 | 0.65 | PKM (0.46) | MEN1KMT2APOLBGAANPC1 | |
| SCHEMBL10600447 | 0.64 | ALDH1A1 (0.41) | HPGDALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3455720 | 0.64 | SMN1; SMN2 (0.54) | LMNAHPGDALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |