Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.56 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380247 | 0.83 | POLB (0.68) | MEN1KMT2ASLC40A1ALDH1A1HTT | |
| SCHEMBL790693 | 0.81 | SLC40A1 (0.59) | KEAP1NFE2L2MEN1KMT2ASLC40A1 | |
| SCHEMBL27179845 | 0.79 | NCOA1 (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL789616 | 0.76 | KEAP1 (0.72) | KEAP1NFE2L2MEN1KMT2AALDH1A1 | |
| SCHEMBL7572319 | 0.76 | POLB (0.68) | KEAP1NFE2L2MEN1KMT2AALDH1A1 | |
| SCHEMBL7571620 | 0.76 | POLB (0.68) | KEAP1NFE2L2MEN1KMT2AALDH1A1 | |
| SCHEMBL28451894 | 0.76 | SLC22A12 (0.74) | SLC40A1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL9954104 | 0.75 | GAA (0.81) | KEAP1NFE2L2MEN1KMT2ASLC40A1 | |
| SCHEMBL789565 | 0.75 | PIK3CA (0.57) | KEAP1NFE2L2PIK3CDSLC40A1GLO1 | |
| SCHEMBL2835167 | 0.75 | POLB (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |