Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170800 | 0.80 | APP (0.78) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL439935 | 0.80 | APP (0.64) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL14947048 | 0.80 | APP (0.78) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL458178 | 0.80 | APP (0.78) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL458177 | 0.80 | APP (0.78) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL9170804 | 0.80 | APP (0.78) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL27909482 | 0.79 | ALDH1A1 (0.72) | APPALDH1A1ACHEHSD17B10LMNA | |
| SCHEMBL22567 | 0.79 | ALDH1A1 (0.72) | APPALDH1A1ACHEHSD17B10LMNA | |
| SCHEMBL1157 | 0.78 | APP (0.61) | APPFBP1MAPTNPC1RAB9A | |
| SCHEMBL8731305 | 0.78 | APP (0.61) | APPFBP1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760042-A | INHIBITOR OF PHOSPHODIESTERASES | SANKYO COMPANY, LIMITED (JP) | 1998-06-02 | — | — | US | claimed |
| US-5021439-A | Senile dementia and memory dysfunction | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-04 | — | — | US | claimed |
| EP-0214708-B1 | GRISEOLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANKYO COMPANY LIMITED (JP) | 1989-12-13 | — | — | EP | claimed |
| US-4883868-A | 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | claimed |
| EP-0271064-A2 | 7-Amino-3-(substituted isoindolinium)methyl-3-cephem derivatives and process for their production | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-06-15 | — | — | EP | claimed |
| EP-0214708-A2 | Griseolic acid derivatives, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1987-03-18 | — | — | EP | claimed |
| US-4232032-A | GROWTH PROMOTERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-11-04 | — | — | US | claimed |
| US-5760042-A | INHIBITOR OF PHOSPHODIESTERASES | SANKYO COMPANY, LIMITED (JP) | 1998-06-02 | — | — | US | disclosed |
| US-5616600-A | Griseolic acid compounds and their use as a phosphodiesterase inhibitor | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5556975-A | CYCLIC GMP PHOSPHODIESTERASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5532369-A | NUCLEOTIDE INHIBITORS OF PHOSPHODIESTERASE | SANKYO COMPANY, LIMITED (JP) | 1996-07-02 | — | — | US | disclosed |
| US-5498819-A | INHIBITORS OF PHOSPHODIESTERASE AS NEUROTROPIC AGENTS, ANTIINFLAMMATORY AGENTS, MUSCLE RELAXANTS, ANTICARCINOGENIC AGENTS AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1996-03-12 | — | — | US | disclosed |
| US-5021439-A | Senile dementia and memory dysfunction | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| US-4370478-A | Oxacephalosporins | RHONE-POULENC INDUSTRIES (FR) | 1983-01-25 | — | — | US | disclosed |
| US-4369315-A | ANTIBIOTIC | RHONE-POULENC INDUSTRIES (FR) | 1983-01-18 | — | — | US | disclosed |
| US-4369314-A | Oxacephalosporins | RHONE-POULENC INDUSTRIES (FR) | 1983-01-18 | — | — | US | disclosed |
| US-4296236-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1981-10-20 | — | — | US | disclosed |
| US-4232032-A | GROWTH PROMOTERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-11-04 | — | — | US | disclosed |
| US-4203896-A | WITH MERCURIC ACETATE AND ACETIC ACID, ACIDIC HYDROLYSIS OF N-PROPENYL GROUP | ELI LILLY AND COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4144232-A | Substituted azetidin-2-one antibiotics | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |