Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARS1 | P26639 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8706028 | 0.92 | MAPT (0.41) | TARS1FFAR1ITGB3ITGAVCTSK | |
| SCHEMBL8706016 | 0.91 | NPC1 (0.44) | ITGB3ITGAVMMP13MAPT | |
| SCHEMBL8709540 | 0.89 | ITGB3 (0.43) | ITGB3ITGAVCTSKCTSSMMP9 | |
| SCHEMBL8709039 | 0.88 | BCL9 (0.40) | ITGB3ITGAVMMP9MMP2MMP13 | |
| SCHEMBL8711199 | 0.87 | MRGPRX4 (0.41) | ITGB3ITGAVMMP13MAPT | |
| SCHEMBL8708878 | 0.87 | LARS1 (0.43) | TARS1ITGB3ITGAVMMEACE | |
| SCHEMBL8705444 | 0.86 | PTGES (0.43) | ITGB3ITGAVPTGESMAPT | |
| SCHEMBL8705895 | 0.86 | ALDH1A1 (0.41) | TARS1ITGB3ITGAVMAPT | |
| SCHEMBL8707231 | 0.85 | SLC7A5 (0.39) | ITGB3ITGAVMMP13MAPT | |
| SCHEMBL8709051 | 0.85 | MAPT (0.39) | ITGB3ITGAVMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998041515-A1 | ENDOTHOLIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-24 | — | — | WO | disclosed |