SCHEMBL8714282

SCHEMBL8714282

CCC(C)(C)NC(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 2/20 0.57
TAS1R1 Q7RTX1 2/20 0.57
TAS1R2 Q8TE23 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.52
NPSR1 Q6W5P4 1/20 0.52
F2R P25116 1/20 0.49
P2RX7 Q99572 3/20 0.49
TSHR P16473 1/20 0.47
JAK2 O60674 1/20 0.47
ERCC5 P28715 1/20 0.46
FEN1 P39748 1/20 0.46
MEN1 O00255 1/20 0.44
MAPK1 P28482 1/20 0.44
KMT2A Q03164 1/20 0.44
TMEM97 Q5BJF2 1/20 0.44
SIGMAR1 Q99720 1/20 0.44
GPR139 Q6DWJ6 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18408979 0.87 L3MBTL1 (0.58) L3MBTL1NPSR1F2R
SCHEMBL14036519 0.85 L3MBTL1 (0.50) TAS1R3TAS1R1TAS1R2L3MBTL1NPSR1
SCHEMBL18177833 0.83 MEN1 (0.57) TAS1R3TAS1R1TAS1R2F2RP2RX7
SCHEMBL28474196 0.81 L3MBTL1 (0.49) TAS1R3TAS1R1TAS1R2L3MBTL1NPSR1
SCHEMBL29643347 0.81 L3MBTL1 (0.49) TAS1R3TAS1R1TAS1R2L3MBTL1NPSR1
SCHEMBL15720276 0.78 TAS1R3 (0.50) TAS1R3TAS1R1TAS1R2F2RP2RX7
SCHEMBL4158170 0.77 TAS1R3 (0.64) TAS1R3TAS1R1TAS1R2F2RP2RX7
SCHEMBL14036676 0.76 NPSR1 (0.60) L3MBTL1NPSR1TSHRMEN1MAPK1
SCHEMBL13590979 0.76 NPSR1 (0.64) L3MBTL1NPSR1MEN1KMT2A
SCHEMBL13985162 0.75 NPSR1 (0.56) L3MBTL1NPSR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10351883-B2 Compounds for increasing lipid synthesis and storage NUTECH VENTURES (US) 2019-07-16 US disclosed
EP-0851790-A1 THE APPLICATION OF DRY SPREADABLE WATER DISPERSIBLE GRANULE COMPOSITIONS RHONE-POULENC INC. (US) 1998-07-08 EP disclosed
WO-1997004864-A1 THE APPLICATION OF DRY SPREADABLE WATER DISPERSIBLE GRANULE COMPOSITIONS RHONE-POULENC INC. (US) 1997-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10351883-B2 Compounds for increasing lipid synthesis and storage FASN, LIPC, SREBF2 TAS1R3 4829/4885TAS1R1 4816/4885TAS1R2 4780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.