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SCHEMBL8714689

SCHEMBL8714689

CCN(C(=O)c1ccccc1N1CCC(C(=O)c2ccc(F)cc2)CC1)c1ccc(C)cc1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 9/20 0.50
▸ HTT P42858 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ LMNA P02545 3/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ ALDH1A1 P00352 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ MEN1 O00255 1/20 0.44
▸ UBE2N P61088 1/20 0.44
▸ BLM P54132 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714721 0.96 HTT (0.53) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8712536 0.93 HTT (0.53) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8716899 0.91 HTT (0.49) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8716870 0.91 MGLL (0.49) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8714643 0.90 HSD11B1 (0.51) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8712324 0.90 HSD11B1 (0.53) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8715137 0.90 HSD11B1 (0.49) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8717776 0.85 HTT (0.47) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8717997 0.85 HTT (0.47) HSD11B1HTTTDP1LMNAKMT2A
SCHEMBL8712275 0.84 HSD11B1 (0.54) HSD11B1HTTTDP1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5728835-A HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS TOA EIYO, LTD. (JP) 1998-03-17 — — US disclosed