Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712536 | 0.90 | HTT (0.53) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8714721 | 0.89 | HTT (0.53) | HTTTDP1SLC18A3HSD11B1LMNA | |
| SCHEMBL8714689 | 0.85 | HSD11B1 (0.50) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8714643 | 0.85 | HSD11B1 (0.51) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8716870 | 0.84 | MGLL (0.49) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8716899 | 0.84 | HTT (0.49) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8717997 | 0.84 | HTT (0.47) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8715137 | 0.83 | HSD11B1 (0.49) | HTTTDP1SLC18A3HSD11B1LMNA | |
| SCHEMBL8712324 | 0.83 | HSD11B1 (0.53) | HTTTDP1HSD11B1LMNAKMT2A | |
| SCHEMBL8716537 | 0.83 | HSD11B1 (0.53) | HTTTDP1SLC18A3HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |