SCHEMBL871495

SCHEMBL871495

COc1ccc(C(Br)c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.56
CA4 P22748 1/20 0.54
LTA4H P09960 2/20 0.52
ALDH1A1 P00352 4/20 0.52
PBRM1 Q86U86 1/20 0.50
PKM P14618 1/20 0.49
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
TRPA1 O75762 1/20 0.47
NR3C1 P04150 1/20 0.46
PGR P06401 1/20 0.46
NR3C2 P08235 1/20 0.46
AR P10275 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
TDP1 Q9NUW8 2/20 0.45
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL119132 0.91 CA1 (0.58) ACP3CA4ALDH1A1CA12CA1
SCHEMBL9160904 0.87 ACP3 (0.56) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL7593429 0.83 ACP3 (0.61) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL5941221 0.82 PBRM1 (0.62) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL8429413 0.82 PBRM1 (0.62) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL13295540 0.82 SLC2A1 (0.61) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL40557 0.82 SLC2A1 (0.61) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL13295537 0.82 SLC2A1 (0.61) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL14205685 0.82 SLC2A1 (0.61) ACP3CA4LTA4HALDH1A1PBRM1
SCHEMBL34971 0.82 SLC2A1 (0.61) ACP3CA4LTA4HALDH1A1PBRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10183966-B2 Solid phase peptide synthesis via side chain attachment CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A. (GR) 2019-01-22 US disclosed
EP-2440572-B1 LACTAM-BRIDGED MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDES PALATIN TECHNOLOGIES INC (US) 2017-04-05 EP disclosed
US-20160362445-A1 SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A. (GR) 2016-12-15 US disclosed
US-9388212-B2 Solid phase peptide synthesis via side chain attachment CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A. (GR) 2016-07-12 US disclosed
US-9273098-B2 Lactam-bridged melanocortin receptor-specific peptides PALATIN TECHNOLOGIES, INC. (US) 2016-03-01 US disclosed
US-20140235789-A1 SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A. (GR) 2014-08-21 US disclosed
WO-2013098802-A2 SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A. (GR) 2013-07-04 WO disclosed
EP-2440572-A2 LACTAM-BRIDGED MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDES Palatin Technologies, Inc. (US) 2012-04-18 EP disclosed
US-20120077957-A1 Lactam-Bridged Melanocortin Receptor-Specific Peptides PALATIN TECHNOLOGIES, INC. (US) 2012-03-29 US disclosed
WO-2010144341-A2 LACTAM-BRIDGED MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDES PALATIN TECHNOLOGIES, INC. (US) 2010-12-16 WO disclosed
US-6417213-B2 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-09 US disclosed
US-20020035102-A1 Azetidine derivatives, their preparation and medicaments containing them AVENTIS PHARMA S.A. (FR) 2002-03-21 US disclosed
US-20020006944-A1 Tricyclic compounds, their production and use OHKAWA SHIGENORI (JP) 2002-01-17 US disclosed
EP-1112251-A1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM Aventis Pharma S.A. (FR) 2001-07-04 EP disclosed
US-6248766-B1 CARDIOVASCULAR DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-06-19 US disclosed
EP-1062205-A2 INHIBITORS OF PHOSPHOLIPASE ENZYMES GENETICS INSTITUTE, INC. (US) 2000-12-27 EP disclosed
WO-2000015609-A1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA S.A. (FR) 2000-03-23 WO disclosed
WO-1999043654-A2 INHIBITORS OF PHOSPHOLIPASE ENZYMES GENETICS INSTITUTE, INC. (US) 1999-09-02 WO disclosed
EP-0929534-A1 TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS Takeda Pharmaceutical Company Limited (JP) 1999-07-21 EP disclosed
WO-1998013356-A1 TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-04-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077957-A1 Lactam-Bridged Melanocortin Receptor-Specific Peptides MC1R, MC3R, MC4R ACP3 1797/4885CA4 4787/4885LTA4H 3192/4885
US-20160362445-A1 SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT HDGF, VIP, HDGFL3 ACP3 2233/4885CA4 4366/4885LTA4H 2103/4885
US-20140235789-A1 SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT HDGF, VIP, HDGFL3 ACP3 2233/4885CA4 4366/4885LTA4H 2103/4885
US-20020006944-A1 Tricyclic compounds, their production and use CNR1, PTGER1, PTGDR ACP3 4506/4885CA4 2498/4885LTA4H 492/4885
US-20020035102-A1 Azetidine derivatives, their preparation and medicaments containing them CYP11B2, AZI2, CYP2C19 ACP3 3108/4885CA4 1589/4885LTA4H 2942/4885
US-10183966-B2 Solid phase peptide synthesis via side chain attachment HDGF, VIP, HDGFL3 ACP3 2233/4885CA4 4366/4885LTA4H 2103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.