SCHEMBL8715487

SCHEMBL8715487

CC(C[SiH3])c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.58
AOC3 Q16853 2/20 0.52
TRPA1 O75762 4/20 0.50
RIPK1 Q13546 1/20 0.50
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
GFER P55789 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HTR2A P28223 1/20 0.41
HRH1 P35367 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12609388 0.80 RIPK1 (0.63) TAAR1AOC3TRPA1RIPK1
SCHEMBL6280516 0.78 RIPK1 (0.67) TAAR1AOC3TRPA1RIPK1
SCHEMBL3672929 0.78 TRPA1 (0.67) TAAR1AOC3TRPA1RIPK1KDM4E
Benzene SCHEMBL5290987 0.76 TAAR1 (0.61) TAAR1AOC3TRPA1RIPK1ALDH1A1
Lithium SCHEMBL30777534 0.76 RIPK1 (0.64) TAAR1AOC3TRPA1RIPK1
SCHEMBL5213988 0.76 RIPK1 (0.64) TAAR1AOC3TRPA1RIPK1
SCHEMBL136376 0.76 TAAR1 (0.61) TAAR1AOC3TRPA1RIPK1ALDH1A1
SCHEMBL4443642 0.76 TAAR1 (0.61) TAAR1AOC3TRPA1RIPK1ALDH1A1
SCHEMBL17453236 0.76 TAAR1 (0.61) TAAR1AOC3TRPA1RIPK1ALDH1A1
SCHEMBL650369 0.75 HTR2A (0.52) TAAR1HTR2AHRH1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117024419-A Chiral 2-oxazoline-8-imine quinoline compound and metal complex thereof, preparation method and application 浙江大学 2023-11-10 CN disclosed
US-5760263-A Alkylferrocenes containing chlorosilyl groups and their preparation methods KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1998-06-02 US disclosed
US-5527938-A FRIEDEL-CRAFT ALKYLATION OF AROMATIC COMPOUNDS WITH ALLYLCHLOROSILANES USING LEWIS ACID CATALYST KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1996-06-18 US disclosed
US-5523444-A REACTING (SUBSTITUTED)AROMATIC COMPOUNDS WITH ALLYLCHLOROSILANES IN PRESENCE OF LEWIS ACID CATALYSTS KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1996-06-04 US disclosed
US-5386050-A (2-arylpropyl)alkylsilanes and their preparation methods KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1995-01-31 US disclosed