Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680171 | 0.81 | NR1I2 (0.38) | NR1I2KIF11TDO2 | |
| SCHEMBL6063293 | 0.81 | NR1I2 (0.38) | NR1I2KIF11TDO2 | |
| SCHEMBL17962916 | 0.78 | NR1I2 (0.36) | NR1I2TDO2 | |
| SCHEMBL8718909 | 0.74 | CA1 (0.38) | KIF11 | |
| SCHEMBL8680470 | 0.74 | KIF11 (0.41) | NR1I2KIF11 | |
| SCHEMBL28898073 | 0.70 | ALDH1A1 (0.46) | — | |
| SCHEMBL4027510 | 0.69 | NR1I2 (0.35) | NR1I2KIF11 | |
| SCHEMBL7196050 | 0.66 | NR1I2 (0.32) | NR1I2KIF11 | |
| SCHEMBL1415048 | 0.66 | LMNA (0.34) | NR1I2 | |
| SCHEMBL1680164 | 0.65 | NR1I2 (0.31) | NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722448-A4 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693648-A | TREATMENT OF AUTOIMMUNE DISEASES, INFECTIOUS DISEASES, PREVENTING REJECTION OF ORGAN TRANSPLANTS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5565560-A | TREATING AUTOIMMUNE DISEASES, PREVENTING TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0722448-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO. INC. (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5532248-A | O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity | MERCK CO., INC. (US) | 1996-07-02 | — | — | US | disclosed |
| WO-1995009857-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| US-5262533-A | Autoimmune diseases or prevention of organ rejection or antiinflammatory agents | MERCK & CO., INC. (US) | 1993-11-16 | — | — | US | disclosed |
| US-5250678-A | For autoimmune, infectious diseases, organ transplant rejection; skin diseases, antiinflammatory agents | MERCK & CO., INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0530888-A1 | Fluoromacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5189042-A | Treating autoimmune diseases, preventing transplant rejection | MERCK & CO. INC. (US) | 1993-02-23 | — | — | US | disclosed |
| WO-1992020688-A1 | AMINO O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL MACROLIDES | MERCK & CO., INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0515071-A2 | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1992-11-25 | — | — | EP | disclosed |