SCHEMBL1680171

SCHEMBL1680171

C[SiH](C)Oc1c(Br)ccc2cc(C(C)(C)C)ccc12

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 1/20 0.38
TDO2 P48775 1/20 0.32
KIF11 P52732 2/20 0.31
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
ALOX15 P16050 1/20 0.30
HSD17B10 Q99714 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6063293 0.82 NR1I2 (0.38) NR1I2TDO2KIF11ALDH1A1HPGD
SCHEMBL8715669 0.81 NR1I2 (0.37) NR1I2TDO2KIF11
SCHEMBL17962916 0.79 NR1I2 (0.36) NR1I2TDO2ALDH1A1HPGDALOX15
SCHEMBL8680470 0.75 KIF11 (0.41) NR1I2KIF11ALDH1A1HPGDTDP1
SCHEMBL3378773 0.74 CA1 (0.39) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL1415048 0.73 LMNA (0.34) NR1I2ALDH1A1
SCHEMBL1793776 0.72 CA1 (0.38) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL5754020 0.71
SCHEMBL28898073 0.71 ALDH1A1 (0.46) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL4027510 0.70 NR1I2 (0.35) NR1I2KIF11ALDH1A1HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011041529-A2 TRI-2-NAPHTHYLAMINES ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2011-04-07 WO disclosed
US-7267892-B2 Electroluminescent devices having pendant naphthylanthracene-based polymers EASTMAN KODAK COMPANY (US) 2007-09-11 US disclosed
US-20070187673-A1 ELECTROLUMINESCENT DEVICES HAVING PENDANT NAPHTHYLANTHRACENE-BASED POLYMERS EASTMAN KODAK COMANY 2007-08-16 US disclosed
EP-0963996-B9 Transition metal compound, catalyst component and catalyst for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORP (JP) 2006-09-06 EP disclosed
EP-0963996-B1 Transition metal compound, catalyst component and catalyst for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORP (JP) 2006-05-24 EP disclosed
US-6899963-B1 Electroluminescent devices having pendant naphthylanthracene-based polymers EASTMAN KODAK COMPANY (US) 2005-05-31 US disclosed
US-6509426-B2 Dichloro(1,1'-dimethylsilylenebis(2-methyl-4-(4-methoxyphenyl) -4H-azulenyl))zirconium, for example; can produce polyolefin with high molecular weight and high melting point for extrusion or injection moldability JAPAN POLYCHEM CORPORATION (JP) 2003-01-21 US disclosed
US-20010023296-A1 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORPORATION (JP) 2001-09-20 US disclosed
US-6218558-B1 BRIDGED OXYGEN-, NITROGEN- OR SULFUR-CONTAINING METALLOCENE CATALYST CONTAINING AT LEAST CYCLOPENTADIENE RING FUSED TO A C7-10 RING JAPAN POLYCHEM CORPORATION (JP) 2001-04-17 US disclosed
EP-0963996-A2 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer Japan Polychem Corporation (JP) 1999-12-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010023296-A1 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer OSTC, TCP1, COG1 NR1I2 1685/4885TDO2 871/4885KIF11 1617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.