Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9243625 | 1.00 | CYSLTR1 (0.40) | CYSLTR1CYSLTR2ALOX5APALOX5GPBAR1 | |
| SCHEMBL8715302 | 0.89 | CYP1A2 (0.37) | CYSLTR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL9248655 | 0.89 | CYP1A2 (0.37) | CYSLTR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL9244337 | 0.81 | PDE10A (0.35) | CYSLTR1CYSLTR2ALOX5APALOX5BRD4 | |
| SCHEMBL9244356 | 0.81 | PDE10A (0.35) | CYSLTR1CYSLTR2ALOX5APALOX5BRD4 | |
| SCHEMBL9244345 | 0.81 | ALOX5AP (0.37) | CYSLTR1CYSLTR2ALOX5APALOX5GPBAR1 | |
| SCHEMBL9249921 | 0.81 | REN (0.37) | CYSLTR1CYSLTR2ALOX5APALOX5BRD4 | |
| SCHEMBL8715307 | 0.78 | LTB4R (0.35) | — | |
| SCHEMBL8715857 | 0.77 | ALOX5AP (0.38) | CYSLTR1CYSLTR2ALOX5APALOX5GPBAR1 | |
| SCHEMBL9244554 | 0.77 | ALOX5AP (0.38) | CYSLTR1CYSLTR2ALOX5APALOX5GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719291-A | FUNGICIDE | HOFFMANN-LA ROCHE INC. (US) | 1998-02-17 | — | — | US | disclosed |
| US-5449785-A | Fungicides with triazole groups | HOFFMANN-LA ROCHE INC. (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0524439-A1 | Novel cyclohexane and tetrahydropyran derivatives and antifungal compositions containing these derivatives | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-01-27 | — | — | EP | disclosed |