Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | HLCS | P50747 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068607 | 0.81 | ALDH1A1 (0.38) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL6360842 | 0.80 | LMNA (0.47) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL9186739 | 0.80 | ALDH1A1 (0.44) | ALDH1A1LMNAMEN1KMT2APTGS1 | |
| SCHEMBL11492447 | 0.80 | ALDH1A1 (0.35) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL11491775 | 0.79 | ALDH1A1 (0.42) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL11483368 | 0.78 | ALDH1A1 (0.38) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL11492446 | 0.77 | ADH1B (0.36) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL11486565 | 0.77 | GAA (0.34) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL11495094 | 0.77 | ALDH1A1 (0.43) | ALDH1A1LMNAHLCSMEN1KMT2A | |
| SCHEMBL12099135 | 0.77 | LMNA (0.47) | ALDH1A1LMNAADORA3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |