Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709649 | 0.82 | GSR (0.40) | RNPEPCPB2GSRFOLH1CYP1A2 | |
| SCHEMBL7226730 | 0.82 | CPB2 (0.38) | RNPEPCPB2GSRFOLH1SLC6A5 | |
| SCHEMBL7224443 | 0.82 | CPB2 (0.41) | RNPEPCPB2GSRFOLH1 | |
| SCHEMBL8712693 | 0.80 | CPB2 (0.37) | RNPEPCPB2GSRFOLH1GABRR1 | |
| SCHEMBL8714819 | 0.79 | CPB2 (0.43) | RNPEPCPB2GSRFOLH1PAOX | |
| SCHEMBL8931801 | 0.78 | SLC6A5 (0.45) | RNPEPCPB2GSRSLC6A5 | |
| SCHEMBL8931799 | 0.78 | SLC6A5 (0.45) | RNPEPCPB2GSRSLC6A5 | |
| SCHEMBL1886103 | 0.77 | GSR (0.43) | RNPEPCPB2GSRFOLH1SLC6A5 | |
| SCHEMBL1886100 | 0.77 | GSR (0.43) | RNPEPCPB2GSRFOLH1SLC6A5 | |
| SCHEMBL9314956 | 0.77 | SLC6A5 (0.47) | CPB2GSRSLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |