Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | BTN3A1 | O00481 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ENO1 | P06733 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 3/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681950 | 0.89 | PRKCA (0.46) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL434232 | 0.82 | PRKCA (0.42) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL10403142 | 0.80 | POLB (0.43) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL203641 | 0.80 | PRKCA (0.41) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL6840326 | 0.80 | ALDH1A1 (0.42) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL4482845 | 0.80 | GAA (0.46) | PRKCABTN3A1ALDH1A1POLBGAA | |
| Bis(Pivaloyloxymethyl) Succinate SCHEMBL3123390 | 0.80 | PRKCA (0.41) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL5534787 | 0.79 | PRKCA (0.43) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL27999368 | 0.79 | PRKCA (0.43) | PRKCABTN3A1ALDH1A1POLBGAA | |
| SCHEMBL8893353 | 0.78 | PRKCA (0.39) | PRKCABTN3A1ALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760042-A | INHIBITOR OF PHOSPHODIESTERASES | SANKYO COMPANY, LIMITED (JP) | 1998-06-02 | — | — | US | disclosed |
| US-5616600-A | Griseolic acid compounds and their use as a phosphodiesterase inhibitor | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5556975-A | CYCLIC GMP PHOSPHODIESTERASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5532369-A | NUCLEOTIDE INHIBITORS OF PHOSPHODIESTERASE | SANKYO COMPANY, LIMITED (JP) | 1996-07-02 | — | — | US | disclosed |
| US-5498819-A | INHIBITORS OF PHOSPHODIESTERASE AS NEUROTROPIC AGENTS, ANTIINFLAMMATORY AGENTS, MUSCLE RELAXANTS, ANTICARCINOGENIC AGENTS AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0318060-B1 | Griseolic acid derivatives, their preparation and their use | SANKYO CO (JP) | 1995-10-25 | — | — | EP | disclosed |
| EP-0319050-B1 | Griseolic acid derivatives, their preparation and their use | SANKYO CO (JP) | 1995-04-12 | — | — | EP | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |
| US-4914206-A | ANTIBIOTICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-04-03 | — | — | US | disclosed |
| US-4891363-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY LIMITED (JP) | 1990-01-02 | — | — | US | disclosed |
| EP-0214708-B1 | GRISEOLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANKYO COMPANY LIMITED (JP) | 1989-12-13 | — | — | EP | disclosed |
| EP-0319050-A2 | Griseolic acid derivatives, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1989-06-07 | — | — | EP | disclosed |
| EP-0318060-A2 | Griseolic acid derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1989-05-31 | — | — | EP | disclosed |
| EP-0251827-A2 | New cyclic ether derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-01-07 | — | — | EP | disclosed |
| EP-0226896-A2 | Lankacidin derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1987-07-01 | — | — | EP | disclosed |
| EP-0214708-A2 | Griseolic acid derivatives, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1987-03-18 | — | — | EP | disclosed |