Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 15/20 | 0.64 |
| ▸ | MEN1 | O00255 | 14/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8711149 | 0.87 | KMT2A (0.59) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8585347 | 0.87 | KMT2A (0.53) | KMT2AMEN1GAAALDH1A1HTT | |
| SCHEMBL8476137 | 0.86 | HSD17B10 (0.51) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8660441 | 0.85 | MEN1 (0.50) | KMT2AMEN1GAAMAPTHCRTR1 | |
| SCHEMBL8915515 | 0.85 | KMT2A (0.59) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8663215 | 0.85 | KMT2A (0.59) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8714576 | 0.84 | KMT2A (0.47) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8698121 | 0.83 | MEN1 (0.73) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8672827 | 0.82 | MEN1 (0.48) | KMT2AMEN1LMNAGAASMN1; SMN2 | |
| SCHEMBL8661948 | 0.82 | MEN1 (0.55) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821372-A | USEFUL FOR INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEIN LEVELS(HDL) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-13 | — | — | US | claimed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | claimed |
| US-5821372-A | USEFUL FOR INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEIN LEVELS(HDL) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-13 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |